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LOC126807510 BRD4-independent group 4 enhancer GRCh37_chr5:132555882-132557081 [ Homo sapiens (human) ]

Gene ID: 126807510, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807510
Gene description
BRD4-independent group 4 enhancer GRCh37_chr5:132555882-132557081
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807510 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (133220190..133221389)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133739903..133741102)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132531489-132531990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132535193-132535692 Neighboring gene ribosomal protein L6 pseudogene 15 Neighboring gene uncharacterized CTB-49A3.2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132571312-132572176 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:132575776-132576276 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:132576277-132576777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:132579499-132580020 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:132581181-132582380 Neighboring gene uncharacterized LOC124901067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132598157-132598658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23103 Neighboring gene follistatin like 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132649525-132650026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132650027-132650526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:132654697-132655214 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:132655215-132655731 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:132663701-132664408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132664409-132665116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:132667351-132667874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132667875-132668398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132676759-132677258 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:132677626-132677813 Neighboring gene uncharacterized LOC124901068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132699589-132700090 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:132700914-132701437 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:132706200-132707399

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083824.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    133220190..133221389
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    133739903..133741102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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