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LOC126807472 MED14-independent group 3 enhancer GRCh37_chr5:106946073-106947272 [ Homo sapiens (human) ]

Gene ID: 126807472, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807472
Gene description
MED14-independent group 3 enhancer GRCh37_chr5:106946073-106947272
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807472 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (107610372..107611571)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (108113213..108114412)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 5 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:106620899-106622098 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:106737319-106737856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22862 Neighboring gene ephrin A5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:106801251-106801752 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:106808214-106808968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22863 Neighboring gene NANOG hESC enhancer GRCh37_chr5:106834891-106835392 Neighboring gene Sharpr-MPRA regulatory region 8638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16212 Neighboring gene NANOG hESC enhancer GRCh37_chr5:106855351-106855852 Neighboring gene uncharacterized LOC124901038 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:106903957-106904492 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:106906417-106907128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22867 Neighboring gene Sharpr-MPRA regulatory region 13332 Neighboring gene VISTA enhancer hs1734 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:106924851-106925777 Neighboring gene Sharpr-MPRA regulatory region 6875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16215 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:107008991-107009490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16216 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:107031758-107032266 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:107060476-107061675 Neighboring gene ubiquitin specific peptidase 7 (herpes virus-associated) pseudogene Neighboring gene RNA, 7SL, cytoplasmic 782, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083786.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    107610372..107611571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    108113213..108114412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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