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LOC126807380 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:44875560-44876759 [ Homo sapiens (human) ]

Gene ID: 126807380, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807380
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:44875560-44876759
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807380 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (44875458..44876657)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (45129180..45130379)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene MRPS30 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:44808788-44809444 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:44809445-44810100 Neighboring gene mitochondrial ribosomal protein S30 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:44911606-44912309 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:44960236-44960452 Neighboring gene uncharacterized LOC124901180 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:45288792-45289361 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:45385335-45386534 Neighboring gene NANOG hESC enhancer GRCh37_chr5:45398997-45399517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45694855-45695356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45695357-45695856

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083694.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    44875458..44876657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    45129180..45130379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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