U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126807300 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:5145575-5146774 [ Homo sapiens (human) ]

Gene ID: 126807300, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126807300
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:5145575-5146774
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (5145462..5146661)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (5073096..5074295)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAMTS16 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:5139649-5140215 Neighboring gene RN7SK pseudogene 73 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 16 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:5175316-5175816 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:5175817-5176317 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr5:5179213-5179956 and GRCh37_chr5:5179957-5180699 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:5182558-5183381 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:5183382-5184206 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:5199611-5200127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:5241793-5242294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:5242295-5242794 Neighboring gene uncharacterized LOC101929200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:5271408-5272068 Neighboring gene Sharpr-MPRA regulatory region 1512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:5325702-5326669 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:5341091-5341592 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:5341593-5342092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:5352015-5352515 Neighboring gene ALG3 pseudogene 1 Neighboring gene MT-CO1 pseudogene 30

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083621.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    5145462..5146661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    5073096..5074295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases