U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126807289 BRD4-independent group 4 enhancer GRCh37_chr5:2393157-2394356 [ Homo sapiens (human) ]

Gene ID: 126807289, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126807289
Gene description
BRD4-independent group 4 enhancer GRCh37_chr5:2393157-2394356
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC126807289 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (2393043..2394242)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (2308794..2309993)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901166 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:2269269-2269796 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:2269797-2270323 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2299803-2300482 Neighboring gene uncharacterized LOC100506858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2353718-2354218 Neighboring gene NANOG hESC enhancer GRCh37_chr5:2359276-2359777 Neighboring gene uncharacterized LOC124901167 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84195 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2591788-2592348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2592349-2592909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2635417-2636236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:2640855-2641373 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:2655710-2656909 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:2658151-2659350 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:2663143-2663330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:2696278-2696794 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:2697069-2698268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2709931-2710432 Neighboring gene long stress-induced non-coding transcript 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083610.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    2393043..2394242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    2308794..2309993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases