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LOC126807199 BRD4-independent group 4 enhancer GRCh37_chr4:157519367-157520566 [ Homo sapiens (human) ]

Gene ID: 126807199, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807199
Gene description
BRD4-independent group 4 enhancer GRCh37_chr4:157519367-157520566
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807199 in Genome Data Viewer
Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (156598215..156599414)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (159943728..159944927)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15771 Neighboring gene MPRA-validated peak5138 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74949 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:157210831-157211442 Neighboring gene uncharacterized LOC105377508 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74995 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:157426362-157427068 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75051 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:157521211-157521946 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:157526591-157527116 Neighboring gene NANOG hESC enhancer GRCh37_chr4:157555350-157555851 Neighboring gene long intergenic non-protein coding RNA 2272 Neighboring gene NANOG hESC enhancer GRCh37_chr4:157692390-157692891 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:157718592-157719092 Neighboring gene platelet derived growth factor C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:157892738-157893238

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083520.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    156598215..156599414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    159943728..159944927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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