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LOC126807195 BRD4-independent group 4 enhancer GRCh37_chr4:153892920-153894119 [ Homo sapiens (human) ]

Gene ID: 126807195, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807195
Gene description
BRD4-independent group 4 enhancer GRCh37_chr4:153892920-153894119
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807195 in Genome Data Viewer
Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (152971768..152972967)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (156294980..156296179)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15754 Neighboring gene Sharpr-MPRA regulatory region 8192 Neighboring gene family with sequence similarity 192, member A pseudogene Neighboring gene uncharacterized LOC729870 Neighboring gene FH2 domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153877563-153878382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153894208-153894728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153894729-153895248 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:153912200-153913399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:153913429-153913928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153942327-153943122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153944769-153945310 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:153949611-153950259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154028483-154028983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154033423-154033922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154057659-154058160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15755 Neighboring gene tripartite motif containing 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154127146-154128051 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154130352-154131177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154143059-154143560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154159939-154160440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154160441-154160940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154162218-154162718 Neighboring gene uncharacterized LOC105377496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154178381-154179026 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:154180767-154181283 Neighboring gene RNA, U6 small nuclear 1196, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083516.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    152971768..152972967
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    156294980..156296179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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