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LOC126807151 CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:128607842-128609041 [ Homo sapiens (human) ]

Gene ID: 126807151, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807151
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:128607842-128609041
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807151 in Genome Data Viewer
Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (127686687..127687886)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (130989660..130990859)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724210 Neighboring gene uncharacterized LOC107986312 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73387 Neighboring gene Sharpr-MPRA regulatory region 9584 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:128328664-128328924 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73515 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73569 Neighboring gene Sharpr-MPRA regulatory region 5357 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:128525826-128526649 Neighboring gene uncharacterized LOC105377412 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:128553760-128554299 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128576502-128577102 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128577103-128577701 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:128629462-128630661 Neighboring gene inturned planar cell polarity protein Neighboring gene ReSE screen-validated silencer GRCh37_chr4:128651275-128651432 Neighboring gene uncharacterized LOC105377414 Neighboring gene solute carrier family 25 member 31 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15673 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128703547-128704539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21886 Neighboring gene SOSS complex subunit C-like Neighboring gene heat shock protein family A (Hsp70) member 4 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083472.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    127686687..127687886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    130989660..130990859
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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