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LOC126807127 CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:103521788-103522987 [ Homo sapiens (human) ]

Gene ID: 126807127, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807127
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:103521788-103522987
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
Annotation information
Note: This locus has been reviewed for its involvement in coronavirus biology, and is regulatory element in the vicinity of coronavirus related gene(s).
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Genomic context

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Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (102600631..102601830)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (105914564..105915763)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377621 Neighboring gene zinc finger protein 705A pseudogene Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:103384680-103385180 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:103385181-103385681 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:103398895-103400094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21753 Neighboring gene nuclear factor kappa B subunit 1 Neighboring gene uncharacterized LOC124900742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21754 Neighboring gene uncharacterized LOC105377347 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:103558780-103559280 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:103559281-103559781 Neighboring gene mannosidase beta Neighboring gene ribosomal protein L21 pseudogene 49 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21755 Neighboring gene Sharpr-MPRA regulatory region 2283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:103650639-103651633 Neighboring gene leucine rich repeat containing 37 member A15, pseudogene Neighboring gene keratin 8 pseudogene 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083448.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    102600631..102601830
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    105914564..105915763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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