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LOC126807015 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:27382868-27384067 [ Homo sapiens (human) ]

Gene ID: 126807015, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807015
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:27382868-27384067
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Another subregion was also validated as an enhancer by ChIP-STARR-seq in primed human embryonic stem cells, where it associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Jan 2023]
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Genomic context

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See LOC126807015 in Genome Data Viewer
Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (27380907..27382445)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (27366428..27367966)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:26912815-26913449 Neighboring gene PIMREG pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 12765 Neighboring gene stromal interaction molecule 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:27018939-27019440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:27019441-27019940 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:27060504-27061703 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:27077097-27077691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:27092736-27093335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:27103164-27103664 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:27123690-27124548 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:27124549-27125407 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:27125408-27126265 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:27218731-27219930 Neighboring gene long intergenic non-protein coding RNA 2261 Neighboring gene uncharacterized LOC124900842 Neighboring gene MPRA-validated peak5014 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:27444283-27445482 Neighboring gene mitochondrial ribosomal protein L51 pseudogene 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:27465247-27466446 Neighboring gene IGBP1 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:27382529-27383100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083336.2 

    Range
    101..1639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    27380907..27382445
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    27366428..27367966
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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