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LOC126807014 BRD4-independent group 4 enhancer GRCh37_chr4:27218731-27219930 [ Homo sapiens (human) ]

Gene ID: 126807014, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807014
Gene description
BRD4-independent group 4 enhancer GRCh37_chr4:27218731-27219930
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807014 in Genome Data Viewer
Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (27217109..27218308)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (27202573..27203772)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15341 Neighboring gene STIM2 antisense RNA 1 Neighboring gene PIMREG pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:26912815-26913449 Neighboring gene Sharpr-MPRA regulatory region 12765 Neighboring gene stromal interaction molecule 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:27018939-27019440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:27019441-27019940 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:27060504-27061703 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:27077097-27077691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:27092736-27093335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:27103164-27103664 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:27123690-27124548 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:27124549-27125407 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:27125408-27126265 Neighboring gene long intergenic non-protein coding RNA 2261 Neighboring gene uncharacterized LOC124900842 Neighboring gene MPRA-validated peak5014 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:27382868-27384067 Neighboring gene mitochondrial ribosomal protein L51 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083335.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    27217109..27218308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    27202573..27203772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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