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LOC126807005 CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:24000845-24002044 [ Homo sapiens (human) ]

Gene ID: 126807005, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807005
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:24000845-24002044
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (23999222..24000421)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (23980894..23982093)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374528 Neighboring gene uncharacterized LOC124900680 Neighboring gene uncharacterized LOC105374527 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:23789763-23790962 Neighboring gene PPARG coactivator 1 alpha Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_77881 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:23887769-23888345 Neighboring gene VISTA enhancer hs2346 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:23933777-23934617 Neighboring gene NANOG hESC enhancer GRCh37_chr4:23974350-23974892 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:23981005-23981707 Neighboring gene NANOG hESC enhancer GRCh37_chr4:24031602-24032103 Neighboring gene Sharpr-MPRA regulatory region 2780 Neighboring gene Sharpr-MPRA regulatory region 10171 Neighboring gene uncharacterized LOC124900679 Neighboring gene NANOG hESC enhancer GRCh37_chr4:24268492-24268993 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:24323096-24323895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:24332192-24332760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:24350443-24351174 Neighboring gene NANOG hESC enhancer GRCh37_chr4:24414779-24415480 Neighboring gene uncharacterized LOC124900678

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083326.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    23999222..24000421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    23980894..23982093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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