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LOC126806992 BRD4-independent group 4 enhancer GRCh37_chr4:16694053-16695252 [ Homo sapiens (human) ]

Gene ID: 126806992, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806992
Gene description
BRD4-independent group 4 enhancer GRCh37_chr4:16694053-16695252
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (16692430..16693629)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (16674131..16675330)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374505 Neighboring gene uncharacterized LOC124900675 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75724 Neighboring gene LIM domain binding 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:16592252-16593021 Neighboring gene uncharacterized LOC124900604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:16610841-16611361 Neighboring gene Sharpr-MPRA regulatory region 15531 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:16777326-16777893 Neighboring gene NANOG hESC enhancer GRCh37_chr4:16819631-16820182 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:16822893-16823118 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:16870067-16870626 Neighboring gene uncharacterized LOC107986188 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:16909825-16910366 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:16910367-16910908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15309 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:16920031-16920848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:16943010-16943510 Neighboring gene Sharpr-MPRA regulatory region 8789 Neighboring gene NANOG hESC enhancer GRCh37_chr4:16979388-16979889 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:16996053-16996798 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:16996799-16997544 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:16998595-16999416 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:16999417-17000236 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:17002080-17002991 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:17004513-17005034 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:17005035-17005556 Neighboring gene NANOG hESC enhancer GRCh37_chr4:17008075-17008615 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:17028696-17029895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:17032946-17033488 Neighboring gene MT-ND5 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083313.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    16692430..16693629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    16674131..16675330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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