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LOC126806974 CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:10807763-10808962 [ Homo sapiens (human) ]

Gene ID: 126806974, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806974
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:10807763-10808962
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806974 in Genome Data Viewer
Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (10806139..10807338)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (10782238..10783437)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene cytokine dependent hematopoietic cell linker Neighboring gene uncharacterized LOC105374480 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:10664724-10664901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15282 Neighboring gene long intergenic non-protein coding RNA 2498 Neighboring gene uncharacterized LOC105374479 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:10855215-10855716 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:10855717-10856216 Neighboring gene NANOG hESC enhancer GRCh37_chr4:10946361-10946898 Neighboring gene Sharpr-MPRA regulatory region 8730 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:10965707-10966380 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:11067600-11068246 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:11150486-11151153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:11218597-11219141 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:11219142-11219685 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:11227260-11227455 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:11232380-11233128 Neighboring gene uncharacterized LOC105374488 Neighboring gene RNA binding protein with serine rich domain 1 pseudogene 1 Neighboring gene microRNA 572

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083295.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    10806139..10807338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    10782238..10783437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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