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LOC126806972 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:10097252-10098451 [ Homo sapiens (human) ]

Gene ID: 126806972, updated on 10-Oct-2023

Summary

Gene symbol
LOC126806972
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:10097252-10098451
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (10095628..10096827)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (10095213..10096414)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900665 Neighboring gene WD repeat domain 1 Neighboring gene microRNA 3138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:10092819-10093589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:10095904-10096674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:10104010-10104700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:10104701-10105391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:10109091-10109822 Neighboring gene Sharpr-MPRA regulatory region 388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:10114947-10115447 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:10117280-10118084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15278 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15279 Neighboring gene uncharacterized LOC124900666 Neighboring gene RNA, 5S ribosomal pseudogene 155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21311

Genomic regions, transcripts, and products

General gene information

Other Names

  • ATAC-STARR-seq lymphoblastoid active region 21308

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083293.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    10095628..10096827
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    10095213..10096414
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    GenBank, FASTA, Sequence Viewer (Graphics)