U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126806969 MED14-independent group 3 enhancer GRCh37_chr4:7172434-7173633 [ Homo sapiens (human) ]

Gene ID: 126806969, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126806969
Gene description
MED14-independent group 3 enhancer GRCh37_chr4:7172434-7173633
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (7170707..7171906)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (7143023..7144222)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15251 Neighboring gene long intergenic non-protein coding RNA 2447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7137065-7137667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7140699-7141354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7141355-7142009 Neighboring gene RN7SK pseudogene 36 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7151654-7152154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7158079-7159057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7162453-7162954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7162955-7163454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7166520-7167020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7167021-7167521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7240587-7241086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7246400-7246900 Neighboring gene sortilin related VPS10 domain containing receptor 2 Neighboring gene uncharacterized LOC105374371 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:7258897-7259058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7259549-7260049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7268122-7268937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7299251-7300056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7300057-7300861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7308243-7308743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7309307-7309806 Neighboring gene microRNA 4798

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083290.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    7170707..7171906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    7143023..7144222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases