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LOC126806927 BRD4-independent group 4 enhancer GRCh37_chr3:194823367-194824566 [ Homo sapiens (human) ]

Gene ID: 126806927, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806927
Gene description
BRD4-independent group 4 enhancer GRCh37_chr3:194823367-194824566
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (195102638..195103837)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (197800303..197801529)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194751125-194752122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194752123-194753121 Neighboring gene Sharpr-MPRA regulatory region 6289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194781985-194782758 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:194789061-194790260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194793833-194794333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194799753-194800269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21037 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_67503 Neighboring gene xyloside xylosyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21040 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:194815702-194816901 Neighboring gene XXYLT1 antisense RNA 1 Neighboring gene uncharacterized LOC124909476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15030 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:194838030-194838572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194838573-194839113 Neighboring gene Sharpr-MPRA regulatory region 14086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194846542-194847072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194859771-194860272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194860273-194860772 Neighboring gene microRNA 3137 Neighboring gene RNA, 7SL, cytoplasmic 36, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083248.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    195102638..195103837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    197800303..197801529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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