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LOC126806915 BRD4-independent group 4 enhancer GRCh37_chr3:193853895-193855094 [ Homo sapiens (human) ]

Gene ID: 126806915, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126806915
Gene description
BRD4-independent group 4 enhancer GRCh37_chr3:193853895-193855094
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC126806915 in Genome Data Viewer
Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (194136106..194137305)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (196832777..196833976)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (193853895..193855094)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2026 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:193714630-193715557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193721507-193722022 Neighboring gene developmental pluripotency associated 2 pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 2028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193749967-193750544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193774732-193775677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193780351-193780851 Neighboring gene uncharacterized LOC102724877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21012 Neighboring gene Sharpr-MPRA regulatory region 14852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21016 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:193858467-193859461 Neighboring gene RNA, 7SL, cytoplasmic 215, pseudogene Neighboring gene uncharacterized LOC107986172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193878773-193879704 Neighboring gene hes family bHLH transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 21015

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083236.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    194136106..194137305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    196832777..196833976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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