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LOC126806869 CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:165177431-165178630 [ Homo sapiens (human) ]

Gene ID: 126806869, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806869
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:165177431-165178630
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806869 in Genome Data Viewer
Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (165459643..165460842)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (168242676..168243875)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374192 Neighboring gene sucrase-isomaltase Neighboring gene long intergenic non-protein coding RNA 1322 Neighboring gene SLIT and NTRK like family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:165290391-165290985 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:165431125-165431624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:165438516-165439016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:165439017-165439517 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20770 Neighboring gene Sharpr-MPRA regulatory region 7963 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:165592326-165593525 Neighboring gene butyrylcholinesterase Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:165702256-165702834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:165743989-165744490 Neighboring gene uncharacterized LOC124909497 Neighboring gene MT-ND4 pseudogene 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083189.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    165459643..165460842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    168242676..168243875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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