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LOC126806794 BRD4-independent group 4 enhancer GRCh37_chr3:124128425-124129624 [ Homo sapiens (human) ]

Gene ID: 126806794, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806794
Gene description
BRD4-independent group 4 enhancer GRCh37_chr3:124128425-124129624
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806794 in Genome Data Viewer
Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (124409578..124410777)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (127135286..127136485)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene kalirin RhoGEF kinase Neighboring gene microRNA 6083 Neighboring gene RNA, U6 small nuclear 143, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:124157584-124158153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:124160859-124161358 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:124209527-124210726 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:124229048-124230247 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:124264307-124264476 Neighboring gene uncharacterized LOC105374076 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:124274537-124274728 Neighboring gene Sharpr-MPRA regulatory region 5497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20396 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20400 Neighboring gene MEMO1 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083114.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    124409578..124410777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    127135286..127136485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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