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LOC126806774 MED14-independent group 3 enhancer GRCh37_chr3:112612841-112614040 [ Homo sapiens (human) ]

Gene ID: 126806774, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806774
Gene description
MED14-independent group 3 enhancer GRCh37_chr3:112612841-112614040
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (112893994..112895193)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (115614938..115616137)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr3:112463594-112464448 Neighboring gene long intergenic non-protein coding RNA 2042 Neighboring gene microRNA 9900 Neighboring gene Sharpr-MPRA regulatory region 12929 Neighboring gene CD200R1L antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112543386-112543886 Neighboring gene CD200 receptor 1 like Neighboring gene ReSE screen-validated silencer GRCh37_chr3:112563646-112563805 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112590118-112590618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112603434-112604024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112604025-112604615 Neighboring gene CD200R1 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64462 Neighboring gene CD200 receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083094.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    112893994..112895193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    115614938..115616137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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