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LOC126806743 CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:94656674-94657873 [ Homo sapiens (human) ]

Gene ID: 126806743, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806743
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:94656674-94657873
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806743 in Genome Data Viewer
Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (94937830..94939029)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (97640415..97641614)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 10 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:94362039-94362654 Neighboring gene uncharacterized LOC105373992 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:94464607-94465130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:94593556-94594056 Neighboring gene long intergenic non-protein coding RNA 879 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:94722999-94723582 Neighboring gene WD repeat domain 82 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:94755350-94755877 Neighboring gene ribosomal protein S18 pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:95006249-95006877 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:95067628-95068442 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083063.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    94937830..94939029
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_019805491.1 Reference GRCh38.p14 PATCHES

    Range
    45720..46919
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    97640415..97641614
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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