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LOC126806724 CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:76518793-76519992 [ Homo sapiens (human) ]

Gene ID: 126806724, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806724
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:76518793-76519992
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806724 in Genome Data Viewer
Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (76469642..76470841)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (76523262..76524461)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene roundabout guidance receptor 2 Neighboring gene uncharacterized LOC124900544 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:76546619-76547252 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71246 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:76600516-76601016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:76601017-76601517 Neighboring gene CAP1 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71345 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71357 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71361 Neighboring gene MPRA-validated peak4710 silencer Neighboring gene uncharacterized LOC102724949 Neighboring gene MPRA-validated peak4713 silencer Neighboring gene MPRA-validated peak4717 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:77039649-77040150 Neighboring gene MPRA-validated peak4719 silencer Neighboring gene MPRA-validated peak4720 silencer Neighboring gene RNA, U6 small nuclear 386, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083044.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    76469642..76470841
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    76523262..76524461
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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