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LOC126806710 CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:69170601-69171800 [ Homo sapiens (human) ]

Gene ID: 126806710, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806710
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:69170601-69171800
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806710 in Genome Data Viewer
Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (69121450..69122649)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (69158264..69159463)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20053 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:69152971-69154170 Neighboring gene ubiquitin like modifier activating enzyme 3 Neighboring gene NANOG hESC enhancer GRCh37_chr3:69160043-69160544 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 5 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:69193854-69194511 Neighboring gene leiomodin 3 Neighboring gene FERM domain containing 4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:69280094-69280858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:69284177-69284678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:69284679-69285178 Neighboring gene NANOG hESC enhancer GRCh37_chr3:69298106-69298630 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:69337315-69338305 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:69434706-69435316 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:69441946-69442574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:69469827-69470328 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:69470329-69470828 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:69511585-69512085 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:69534465-69535137 Neighboring gene RNA binding motif protein 43 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:69560923-69561519 Neighboring gene H1-8 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083030.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    69121450..69122649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    69158264..69159463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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