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LOC126806575 BRD4-independent group 4 enhancer GRCh37_chr2:239154789-239155988 [ Homo sapiens (human) ]

Gene ID: 126806575, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806575
Gene description
BRD4-independent group 4 enhancer GRCh37_chr2:239154789-239155988
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806575 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (238246148..238247347)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (238735886..238737085)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239142883-239143384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239147110-239147678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239149579-239150084 Neighboring gene TARDBP pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239150085-239150590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239156797-239157297 Neighboring gene hes family bHLH transcription factor 6 Neighboring gene period circadian regulator 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239172424-239172924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239179613-239180112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239187958-239188582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239190897-239191397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239192245-239192744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239196189-239196711 Neighboring gene uncharacterized LOC112268433 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:239196796-239197690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17380 Neighboring gene MPRA-validated peak4101 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239223693-239224192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12496 Neighboring gene TRAF3 interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17381 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:239276069-239276272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17382

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082895.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    238246148..238247347
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    238735886..238737085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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