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LOC126806560 CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:235602982-235604181 [ Homo sapiens (human) ]

Gene ID: 126806560, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806560
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:235602982-235604181
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (234694338..234695537)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (235183385..235184584)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:235405987-235406760 Neighboring gene CRISPRi-validated cis-regulatory element chr2.7113 Neighboring gene ADP ribosylation factor like GTPase 4C Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:235471377-235472120 Neighboring gene uncharacterized LOC105373936 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:235505034-235505574 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:235505575-235506115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:235512165-235513116 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:235531433-235532632 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:235549687-235550294 Neighboring gene NANOG hESC enhancer GRCh37_chr2:235570023-235570546 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:235596500-235597125 Neighboring gene Sharpr-MPRA regulatory region 2610 Neighboring gene long intergenic non-protein coding RNA 1173 Neighboring gene NANOG hESC enhancer GRCh37_chr2:235619073-235619654 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:235673486-235674685 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:235680947-235681448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:235681449-235681948 Neighboring gene uncharacterized LOC101927896 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:235742667-235743866 Neighboring gene Sharpr-MPRA regulatory region 15004

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082880.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    234694338..234695537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    235183385..235184584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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