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LOC126806448 BRD4-independent group 4 enhancer GRCh37_chr2:191624535-191625734 [ Homo sapiens (human) ]

Gene ID: 126806448, updated on 10-Oct-2023

Summary

Gene symbol
LOC126806448
Gene description
BRD4-independent group 4 enhancer GRCh37_chr2:191624535-191625734
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (190759809..190761008)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (191249108..191250307)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene NEMP2 divergent transcript Neighboring gene RN7SK pseudogene 179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16861 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:191472316-191473515 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:191501909-191502643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16866 Neighboring gene NGFI-A binding protein 1 Neighboring gene uncharacterized LOC124907946 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5899 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:191655893-191657092 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:191708051-191709250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12185 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:191734008-191734548 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:191734549-191735087 Neighboring gene uncharacterized LOC124906110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12189 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:191746471-191747670 Neighboring gene glutaminase Neighboring gene signal transducer and activator of transcription 1 Neighboring gene RAB1A pseudogene 1

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082768.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    190759809..190761008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    191249108..191250307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)