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LOC126806335 BRD4-independent group 4 enhancer GRCh37_chr2:121301087-121302286 [ Homo sapiens (human) ]

Gene ID: 126806335, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806335
Gene description
BRD4-independent group 4 enhancer GRCh37_chr2:121301087-121302286
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806335 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (120543511..120544710)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (120979073..120980272)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121110159-121110862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121110863-121111564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121114094-121114669 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:121130783-121131676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121133461-121134352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121152410-121153223 Neighboring gene inhibin subunit beta B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121187849-121188837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121199691-121200316 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:121209011-121209167 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:121210803-121212002 Neighboring gene NANOG hESC enhancer GRCh37_chr2:121214333-121214894 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:121223679-121224221 Neighboring gene long intergenic non-protein coding RNA 1101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121256367-121256872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121261397-121261898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121269051-121269670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121269671-121270289 Neighboring gene uncharacterized LOC105373585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121317507-121318008 Neighboring gene NANOG hESC enhancer GRCh37_chr2:121332587-121333189 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121345700-121346593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121352388-121352896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121355088-121355588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121355589-121356089 Neighboring gene Sharpr-MPRA regulatory region 1201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121366968-121367468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121412505-121413005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121419009-121419957 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:121426571-121427770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121463233-121463948 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121466954-121467822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121467823-121468690 Neighboring gene uncharacterized LOC124906073 Neighboring gene uncharacterized LOC124907881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121492073-121492720 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_52581 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:121494648-121495148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:121495149-121495649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121496056-121496893 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121496894-121497730 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:121497887-121498529 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:121498530-121499171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121503217-121503718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121510854-121511369 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121515981-121516842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121526109-121526644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121531159-121531669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121540897-121541818 Neighboring gene Sharpr-MPRA regulatory region 398 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121543663-121544585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121545508-121546430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121547621-121548252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121552862-121553525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121562057-121562706 Neighboring gene GLI family zinc finger 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121565847-121566347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121579379-121580044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121580881-121581688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121581689-121582496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121582497-121583304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121590494-121591486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121603734-121604234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:121613936-121614585 Neighboring gene uncharacterized LOC124907880

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082655.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    120543511..120544710
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    120979073..120980272
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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