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LOC126806182 CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:30440807-30442006 [ Homo sapiens (human) ]

Gene ID: 126806182, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126806182
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:30440807-30442006
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806182 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (30217941..30219140)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (30262178..30263377)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (30440807..30442006)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374414 Neighboring gene uncharacterized LOC124907749 Neighboring gene Sharpr-MPRA regulatory region 12598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30416411-30416970 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:30431474-30431698 Neighboring gene H3 histone pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15534 Neighboring gene Sharpr-MPRA regulatory region 4877 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30453066-30453581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30453582-30454096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11328 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:30459095-30459302 Neighboring gene LBH regulator of WNT signaling pathway Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30488856-30489470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30489471-30490085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15535 Neighboring gene NANOG hESC enhancer GRCh37_chr2:30511920-30512428 Neighboring gene uncharacterized LOC102723594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15537 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:30517185-30517355

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082506.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    30217941..30219140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    30262178..30263377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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