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LOC126806135 CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:10422935-10424134 [ Homo sapiens (human) ]

Gene ID: 126806135, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806135
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:10422935-10424134
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (10282809..10284008)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (10311442..10312641)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907731 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10424193-10424793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10425933-10426432 Neighboring gene uncharacterized LOC101929691 Neighboring gene RNA, 7SL, cytoplasmic 66, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:10429268-10430467 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene CRISPRi-validated cis-regulatory element chr2.403 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10443229-10443426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11161 Neighboring gene hippocalcin like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10459734-10460234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10460235-10460735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10471739-10472326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10484271-10484771 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr2:10508004-10508811 Neighboring gene Sharpr-MPRA regulatory region 2000 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10513139-10513866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10513867-10514592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10522419-10523074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10523075-10523728 Neighboring gene uncharacterized LOC124905972 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:10547784-10548983

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082459.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    10282809..10284008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    10311442..10312641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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