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LOC126806115 CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:6135557-6136756 [ Homo sapiens (human) ]

Gene ID: 126806115, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806115
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:6135557-6136756
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806115 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (5995425..5996624)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (6017389..6018588)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:6114361-6114862 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:6115742-6116395 Neighboring gene sciatic injury induced lincRNA upregulator of SOX11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:6120871-6121617 Neighboring gene uncharacterized LOC400940 Neighboring gene microRNA 7158 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:6193971-6194712 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:6232422-6233621 Neighboring gene NANOG hESC enhancer GRCh37_chr2:6253851-6254352 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:6289007-6289241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15240 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:6378134-6379333 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:6396128-6396341 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:6423042-6423564 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:6431337-6432536 Neighboring gene uncharacterized LOC105373401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15243 Neighboring gene long intergenic non-protein coding RNA 1247

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082439.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    5995425..5996624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    6017389..6018588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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