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LOC126806107 BRD4-independent group 4 enhancer GRCh37_chr2:3034172-3035371 [ Homo sapiens (human) ]

Gene ID: 126806107, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806107
Gene description
BRD4-independent group 4 enhancer GRCh37_chr2:3034172-3035371
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (3030400..3031599)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (3040871..3042066)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15220 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:2775469-2775986 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:2791409-2792013 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:2792014-2792618 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:2792619-2793223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:2796071-2796790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:2796791-2797509 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:2841318-2841951 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:2845889-2846419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2854499-2855406 Neighboring gene uncharacterized LOC124905968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11107 Neighboring gene long intergenic non-protein coding RNA 1250 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:2952587-2953786 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_58239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3038327-3038874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3066843-3067343 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3105730-3106514 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:3108292-3108999 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3112467-3113140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3118175-3118676 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:3131179-3131343 Neighboring gene uncharacterized LOC107985840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3172751-3173696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3182069-3182826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3183585-3184342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3184343-3185098

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082431.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    3030400..3031599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    3040871..3042066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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