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LOC126805988 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:205633133-205634332 [ Homo sapiens (human) ]

Gene ID: 126805988, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805988
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:205633133-205634332
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126805988 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205664005..205665204)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204928640..204929839)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:205569093-205570292 Neighboring gene RNA, U6 small nuclear 418, pseudogene Neighboring gene GABA type A receptor-associated protein pseudogene Neighboring gene ETS transcription factor ELK4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205629205-205629793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205631113-205631667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205631668-205632223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2387 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205639145-205639706 Neighboring gene solute carrier family 45 member 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205644516-205645016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205645017-205645517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1747 Neighboring gene uncharacterized LOC105371701 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205657475-205658431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205662277-205662826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205670015-205670516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205670517-205671016 Neighboring gene nuclear casein kinase and cyclin dependent kinase substrate 1 Neighboring gene small nucleolar RNA SNORA72

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082312.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    205664005..205665204
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    204928640..204929839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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