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LOC126805907 CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:167586581-167587780 [ Homo sapiens (human) ]

Gene ID: 126805907, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805907
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:167586581-167587780
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (167617344..167618543)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (166968800..166969999)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1530 Neighboring gene cellular repressor of E1A stimulated genes 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:167533326-167534525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2042 Neighboring gene ribosomal protein S18 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167604143-167604666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167604667-167605189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2047 Neighboring gene RCSD domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:167625876-167626070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2049 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:167649515-167649718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2050 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:167658487-167659686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167666863-167667545 Neighboring gene Sharpr-MPRA regulatory region 8181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:167682480-167683318 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1534 Neighboring gene tRNA-Pro (anticodon CGG) 1-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082231.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    167617344..167618543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    166968800..166969999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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