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LOC126805839 MED14-independent group 3 enhancer GRCh37_chr1:117421310-117422509 [ Homo sapiens (human) ]

Gene ID: 126805839, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805839
Gene description
MED14-independent group 3 enhancer GRCh37_chr1:117421310-117422509
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA). The major subregion had activity in HCT116 colorectal carcinoma cells, where it was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. Two subregions were also shown to be active enhancers by ChIP-STARR-seq in primed human embryonic stem cells, where both subregions were marked by the H3K27ac and H3K4me1 histone modifications, and one was additionally associated with the NANOG transcription factor. This locus also includes two accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC126805839 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (116878661..116879887)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (116889106..116890332)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD2 5' regulatory region Neighboring gene CD2 molecule Neighboring gene CD2 locus control region Neighboring gene ferritin heavy chain 1 pseudogene 22 Neighboring gene Sharpr-MPRA regulatory region 9503 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:117363109-117363310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1575 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:117403141-117403881 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:117403882-117404621 Neighboring gene Sharpr-MPRA regulatory region 12934 Neighboring gene uncharacterized LOC105378927 Neighboring gene prostaglandin F2 receptor inhibitor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:117481416-117481965 Neighboring gene MPRA-validated peak385 silencer Neighboring gene RNA, 5S ribosomal pseudogene 55

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  3. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 1576
  • ATAC-STARR-seq lymphoblastoid active region 1577
  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:117421815-117422346
  • NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:117421283-117421814

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082163.2 

    Range
    101..1327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    116878661..116879887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    116889106..116890332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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