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LOC126805812 CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:102129620-102130819 [ Homo sapiens (human) ]

Gene ID: 126805812, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805812
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:102129620-102130819
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126805812 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (101664064..101665263)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (101513246..101514445)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723784 Neighboring gene Sharpr-MPRA regulatory region 6134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1400 Neighboring gene long intergenic non-protein coding RNA 1307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1125 Neighboring gene Sharpr-MPRA regulatory region 14885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1410 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:101918390-101919589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1411 Neighboring gene long intergenic non-protein coding RNA 1709 Neighboring gene RNA, U6 small nuclear 965, pseudogene Neighboring gene ribosomal protein SA pseudogene 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082136.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    101664064..101665263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    101513246..101514445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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