U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126805708 BRD4-independent group 4 enhancer GRCh37_chr1:39021300-39022499 [ Homo sapiens (human) ]

Gene ID: 126805708, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126805708
Gene description
BRD4-independent group 4 enhancer GRCh37_chr1:39021300-39022499
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC126805708 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (38555628..38556827)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (38422849..38424048)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38949916-38950676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38950677-38951437 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:38955288-38956062 Neighboring gene long intergenic non-protein coding RNA 1685 Neighboring gene Sharpr-MPRA regulatory region 1530 Neighboring gene uncharacterized LOC105378658 Neighboring gene CRISPRi-validated cis-regulatory element chr1.5052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38995999-38996641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39025118-39025733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39034058-39034665 Neighboring gene MPRA-validated peak186 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:39065535-39066150 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:39066151-39066766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39073721-39074510 Neighboring gene uncharacterized LOC105378660 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:39165731-39165950 Neighboring gene VISTA enhancer hs1031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39206875-39207549 Neighboring gene Sharpr-MPRA regulatory region 12321 Neighboring gene NANOG hESC enhancer GRCh37_chr1:39212546-39213129 Neighboring gene HSPA5 pseudogene 1 Neighboring gene VISTA enhancer hs1139 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:39253877-39254442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39281537-39282038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39282039-39282538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 688 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:39285036-39285203 Neighboring gene Sharpr-MPRA regulatory region 3933 Neighboring gene Ras related GTP binding C

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082032.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    38555628..38556827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    38422849..38424048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases