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LOC126805700 MED14-independent group 3 enhancer GRCh37_chr1:37565375-37566574 [ Homo sapiens (human) ]

Gene ID: 126805700, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805700
Gene description
MED14-independent group 3 enhancer GRCh37_chr1:37565375-37566574
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37099774..37100973)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (36963522..36964721)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904023 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:37235886-37236485 Neighboring gene glutamate ionotropic receptor kainate type subunit 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37306912-37307481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37315505-37316004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37324384-37325242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37389776-37390276 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:37407041-37407936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:37424529-37425095 Neighboring gene MPRA-validated peak179 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:37497871-37498770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:37498771-37499670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37500245-37500806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37500807-37501367 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37503613-37504173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37508295-37508862 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7663 Neighboring gene uncharacterized LOC124904027 Neighboring gene MPRA-validated peak180 silencer Neighboring gene microRNA 4255

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082024.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    37099774..37100973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    36963522..36964721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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