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LOC126805677 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:30446776-30447975 [ Homo sapiens (human) ]

Gene ID: 126805677, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805677
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:30446776-30447975
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. A subregion was also validated as an enhancer by ChIP-STARR-seq in naive and primed human embryonic stem cells, where it associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC126805677 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (29973929..29975128)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (29817161..29818360)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29779419-29779919 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29781005-29781983 Neighboring gene MPRA-validated peak142 silencer Neighboring gene MPRA-validated peak143 silencer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:29798359-29798929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29814305-29814937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29814938-29815569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29826683-29827364 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29827365-29828046 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29828047-29828728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29877072-29877798 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:30042683-30043882 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:30053644-30053840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30058109-30058609 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30064644-30065475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30065476-30066306 Neighboring gene uncharacterized LOC107984934 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:30108561-30108764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30162197-30162696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30179358-30179858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30179859-30180359 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:30182040-30183239 Neighboring gene MPRA-validated peak146 silencer Neighboring gene MPRA-validated peak147 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30257435-30257936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30272801-30273302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30283373-30284343 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:30296971-30297175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30297771-30298270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30317999-30318500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30318501-30319000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:30328550-30329222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:30329223-30329894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:30331015-30331514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:30394348-30395242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:30399701-30400346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:30403757-30404338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:30406301-30407056 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:30454325-30454982 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:30481435-30481935 Neighboring gene Sharpr-MPRA regulatory region 9119 Neighboring gene long intergenic non-protein coding RNA 1648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30579535-30580036 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:30626667-30627480 Neighboring gene uncharacterized LOC105378617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30663183-30663713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:30667220-30667720

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:30446951-30447674

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082001.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    29973929..29975128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    29817161..29818360
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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