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LOC126805666 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:25417097-25418296 [ Homo sapiens (human) ]

Gene ID: 126805666, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805666
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:25417097-25418296
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Another subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it is marked by the H3K4me1 histone modification. [provided by RefSeq, Jan 2023]
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Genomic context

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Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25090361..25091805)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (24926578..24928023)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene enhancer 2 sub-fragment of super enhancer upstream of RUNX3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25351623-25352296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25353935-25354474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25354475-25355012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25355013-25355552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 437 Neighboring gene microRNA 4425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 441 Neighboring gene long intergenic non-protein coding RNA 2793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25372889-25373429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25373430-25373969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25378080-25378598 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:25381310-25381813 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25398512-25399127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 451 Neighboring gene MPRA-validated peak123 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 447 Neighboring gene uncharacterized LOC124903880 Neighboring gene IFITM3 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K4me1 hESC enhancer GRCh37_chr1:25416852-25417534

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081990.2 

    Range
    101..1545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    25090361..25091805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    24926578..24928023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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