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LOC126805626 BRD4-independent group 4 enhancer GRCh37_chr1:15148588-15149787 [ Homo sapiens (human) ]

Gene ID: 126805626, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805626
Gene description
BRD4-independent group 4 enhancer GRCh37_chr1:15148588-15149787
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (14822092..14823291)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (14266108..14267307)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kazrin, periplakin interacting protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15044353-15044920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15052062-15052748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15058239-15058960 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:15058961-15059682 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15059683-15060406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15061129-15061850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15061851-15062572 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:15068552-15069136 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:15069137-15069720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15088664-15089164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15089165-15089665 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15105533-15106063 Neighboring gene tubulin folding cofactor A pseudogene 2 Neighboring gene uncharacterized LOC105376759 Neighboring gene uncharacterized LOC124903848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15152512-15153052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15162451-15162952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15175469-15175968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15194601-15195101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 229 Neighboring gene uncharacterized LOC107985469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15220320-15221320 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:15233506-15234705 Neighboring gene uncharacterized LOC124903849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15249981-15250480

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081950.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    14822092..14823291
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    14266108..14267307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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