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LOC126805601 CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7377679-7378878 [ Homo sapiens (human) ]

Gene ID: 126805601, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805601
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7377679-7378878
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (7317619..7318818)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (6847008..6848207)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:7086000-7087199 Neighboring gene CAMTA1 antisense RNA 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7109791-7110690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 89 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7142559-7142729 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7153467-7153661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7209665-7210272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7234210-7234710 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:7237955-7238455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7284388-7284888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7284889-7285389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7305529-7306030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7344591-7345092 Neighboring gene RNA, U1 small nuclear 8, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7354235-7354752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7395955-7396832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7433523-7434023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7438503-7439129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7439130-7439755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7439756-7440382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7440383-7441007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7448189-7448726 Neighboring gene CAMTA1 intronic transcript 1 Neighboring gene CAMTA1 antisense RNA 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081925.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    7317619..7318818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    6847008..6848207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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