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LOC126805583 CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:3080396-3081595 [ Homo sapiens (human) ]

Gene ID: 126805583, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805583
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:3080396-3081595
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (3163832..3165031)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (2666495..2667694)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2 Neighboring gene opioid growth factor receptor pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2989243-2990091 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:3008649-3008795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3011815-3012660 Neighboring gene PR/SET domain 16 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3023590-3024149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3030215-3030791 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3030792-3031367 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3041525-3042136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3042749-3043359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3044803-3045728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3052001-3052522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3052523-3053044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3054481-3054980 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3062305-3063167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3066095-3066595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3070263-3070764 Neighboring gene microRNA 4251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3070765-3071264 Neighboring gene uncharacterized LOC105378606 Neighboring gene uncharacterized LOC107984909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3105417-3105918 Neighboring gene uncharacterized LOC105378605

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081908.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    3163832..3165031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    2666495..2667694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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