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LOC126653366 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:40051342-40052541 [ Homo sapiens (human) ]

Gene ID: 126653366, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126653366
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:40051342-40052541
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Aug 2022]
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Genomic context

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Location:
chromosome: 21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (38679418..38680617)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (37063198..37064397)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ETS transcription factor ERG Neighboring gene ERG, ETS transcription factor breakpoint cluster recombination region Neighboring gene uncharacterized LOC105372802 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr21:39879001-39879501 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40055463-40056662 Neighboring gene long intergenic non-protein coding RNA 114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18458 Neighboring gene uncharacterized LOC107985480 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40159061-40160260

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081859.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    38679418..38680617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    37063198..37064397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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