PLK5 polo like kinase 5 (inactive) [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLK5provided by HGNC
Official Full Name: polo like kinase 5 (inactive)provided by HGNC
Primary source: HGNC:HGNC:27001
See related: Ensembl:ENSG00000185988 AllianceGenome:HGNC:27001
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PLK-5; PLK5P; SgK384ps
Summary: Predicted to enable ATP binding activity and protein kinase activity. Involved in several processes, including defense response to tumor cell; positive regulation of neuron projection development; and regulation of G1/S transition of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis (RPKM 2.5), endometrium (RPKM 1.6) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (1524077..1536046)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (1494514..1506275)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (1524076..1536045)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we report a three-nucleotide deletion near the C-region of Plk5 that is specifically associated with the lymphatic metastasis in patients with clear cell renal cell carcinoma
Title: Genetic mutations associated with metastatic clear cell renal cell carcinoma.
The human polo-like kinase 5 gene is significantly silenced in astrocytoma and glioblastoma multiforme by promoter hypermethylation, suggesting a tumor suppressor function for this gene.
Title: Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484261

SHGC-147922 (e-PCR)
- UniSTS:176096

RH78029 (e-PCR)
- UniSTS:14839

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to tumor cell	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive serine/threonine-protein kinase PLK5

Names: polo-like kinase 5, pseudogene

NP_001230008.1

EC 2.7.11.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243079.2 → NP_001230008.1 inactive serine/threonine-protein kinase PLK5

See identical proteins and their annotated locations for NP_001230008.1

Status: VALIDATED

Source sequence(s)

AC027307, AI651075, AK054808, BC100791

Consensus CDS

CCDS59328.1

UniProtKB/Swiss-Prot

B3KNR4, Q1ZYM0, Q496M5

UniProtKB/TrEMBL

B3KV28

Related

ENSP00000468376.1, ENST00000454744.7

Conserved Domains (3) summary

cd13118
Location:200 → 275

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cl02916
Location:255 → 336

POLO_box; Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases

cl21453
Location:1 → 65

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

1524077..1536046

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

1494514..1506275

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001011716.1: Suppressed sequence

Description

NM_001011716.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
NR_026557.1: Suppressed sequence

Description

NR_026557.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.