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ZNF57 zinc finger protein 57 [ Homo sapiens (human) ]

Gene ID: 126295, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF57provided by HGNC
Official Full Name
zinc finger protein 57provided by HGNC
Primary source
HGNC:HGNC:13125
See related
Ensembl:ENSG00000171970 AllianceGenome:HGNC:13125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF424
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 9.6), esophagus (RPKM 4.1) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2900928..2918473)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2876161..2892540)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2900926..2918471)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 556 Neighboring gene ribosomal protein L35a pseudogene 38 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2887583-2887760 Neighboring gene zinc finger protein 57 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9816 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:2900543-2901114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13722 Neighboring gene zinc finger protein 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982456-2982974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982975-2983491 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:2984010-2984526 Neighboring gene TLE family member 6, subcortical maternal complex member

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF424 Induces Apoptosis and Inhibits Proliferation in Lung Carcinoma Cells. Liu W, et al. Curr Mol Med, 2018. PMID 29974829, Free PMC Article
  2. ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses NFAT and p21 pathway. Wang Y, et al. BMB Rep, 2010 Mar. PMID 20356463
  3. Characterization and mapping of human genes encoding zinc finger proteins. Bray P, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946370, Free PMC Article
  4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 57
Names
zinc finger protein 424

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319083.2 → NP_001306012.1  zinc finger protein 57 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in the use of a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK302165, EF534355
    Consensus CDS
    CCDS82274.1
    UniProtKB/TrEMBL
    G3V131
    Related
    ENSP00000430223.1, ENST00000523428.5
    Conserved Domains (3) summary
    COG5048
    Location:148 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:222 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:86 → 102
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_173480.3 → NP_775751.1  zinc finger protein 57 isoform 1

    See identical proteins and their annotated locations for NP_775751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    EF534355
    Consensus CDS
    CCDS12098.1
    UniProtKB/Swiss-Prot
    Q68EA5, Q8N6R9
    UniProtKB/TrEMBL
    A5HJR3
    Related
    ENSP00000303696.5, ENST00000306908.10
    Conserved Domains (5) summary
    smart00349
    Location:4 → 44
    KRAB; krueppel associated box
    COG5048
    Location:138 → 546
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254 → 274
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:267 → 291
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    2900928..2918473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527682.3 → XP_011525984.1  zinc finger protein 57 isoform X1

    See identical proteins and their annotated locations for XP_011525984.1

    UniProtKB/TrEMBL
    G3V131
    Conserved Domains (3) summary
    COG5048
    Location:148 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:222 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:86 → 102
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    2876161..2892540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68EA5.3 GenPept UniProtKB/Swiss-Prot:Q68EA5

Gene LinkOut

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