U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cebpd CCAAT/enhancer binding protein delta [ Mus musculus (house mouse) ]

Gene ID: 12609, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Cebpdprovided by MGI
Official Full Name
CCAAT/enhancer binding protein deltaprovided by MGI
Primary source
MGI:MGI:103573
See related
Ensembl:ENSMUSG00000071637 AllianceGenome:MGI:103573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c/EBPdelta
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; integumental system; and lung. Orthologous to human CEBPD (CCAAT enhancer binding protein delta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cebpd in Genome Data Viewer
Location:
16 A2; 16 10.09 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (15705150..15707409)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (15887286..15889545)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:15863142-15863251 Neighboring gene STARR-positive B cell enhancer ABC_E5527 Neighboring gene mitotic spindle organizing protein 2 Neighboring gene predicted gene, 41425 Neighboring gene STARR-seq mESC enhancer starr_40217 Neighboring gene 60S ribosomal protein L30-like Neighboring gene scaffolding protein involved in DNA repair Neighboring gene STARR-seq mESC enhancer starr_40218 Neighboring gene STARR-positive B cell enhancer mm9_chr16:15984736-15985037 Neighboring gene predicted gene 10121 Neighboring gene STARR-seq mESC enhancer starr_40221 Neighboring gene folate receptor 1 (adult) pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy. Duitman J, et al. Lab Invest, 2014 Jan. PMID 24247561
  2. Loss of C/EBPδ enhances apoptosis of intestinal epithelial cells and exacerbates experimental colitis in mice. Jozawa H, et al. Genes Cells, 2019 Sep. PMID 31233664
  3. Loss of C/EBPδ Exacerbates Radiation-Induced Cognitive Decline in Aged Mice due to Impaired Oxidative Stress Response. Banerjee S, et al. Int J Mol Sci, 2019 Feb 18. PMID 30781689, Free PMC Article
  4. CCAAT/enhancer binding protein-delta expression is increased in fast skeletal muscle by food deprivation and regulates myostatin transcription in vitro. Allen DL, et al. Am J Physiol Regul Integr Comp Physiol, 2010 Dec. PMID 20844262, Free PMC Article
  5. CCAAT/enhancer binding protein delta in microglial activation. Ejarque-Ortiz A, et al. J Neurosci Res, 2010 Apr. PMID 19908286

See all (176) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPA1 promotes adipogenesis by regulating the stability of C/EBPs.
    Title: PPA1 promotes adipogenesis by regulating the stability of C/EBPs.
  2. C/EBPdelta Mediates Immunity to Renal Autoinflammatory Disorders in a Stage-specific Manner.
    Title: C/EBPδ Mediates Immunity to Renal Autoinflammatory Disorders in a Stage-specific Manner.
  3. CEBPD REGULATES OXIDATIVE STRESS AND INFLAMMATORY RESPONSES IN HYPERTENSIVE CARDIAC REMODELING.
    Title: CEBPD REGULATES OXIDATIVE STRESS AND INFLAMMATORY RESPONSES IN HYPERTENSIVE CARDIAC REMODELING.
  4. Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
    Title: Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
  5. C/EBPdelta-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9.
    Title: C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9.
  6. FOXO1 cooperates with C/EBPdelta and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting.
    Title: FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting.
  7. C/EBPdelta drives key endocrine signals in the human amnion at parturition.
    Title: C/EBPδ drives key endocrine signals in the human amnion at parturition.
  8. CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs.
    Title: CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs.
  9. Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation.
    Title: Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation.
  10. Activation of the beta-adrenergic receptor exacerbates lipopolysaccharide-induced wasting of skeletal muscle cells by increasing interleukin-6 production.
    Title: Activation of the β-adrenergic receptor exacerbates lipopolysaccharide-induced wasting of skeletal muscle cells by increasing interleukin-6 production.
Submit: New GeneRIF Correction See all GeneRIFs (96)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fat cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
CCAAT/enhancer-binding protein delta
Names
C/EBP delta
CCAAT/enhancer binding protein (C/EBP), delta
c/EBP-related protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007679.4 → NP_031705.3  CCAAT/enhancer-binding protein delta

    See identical proteins and their annotated locations for NP_031705.3

    Status: VALIDATED

    Source sequence(s)
    AK053190, AK149723, AK151958
    Consensus CDS
    CCDS84207.1
    UniProtKB/Swiss-Prot
    Q00322, Q3U937, Q8BW92
    UniProtKB/TrEMBL
    B9EIA9, Q3U0K9
    Related
    ENSMUSP00000148145.2, ENSMUST00000096232.6
    Conserved Domains (1) summary
    cd14714
    Location:188 → 252
    bZIP_CEBPD; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein delta (CEBPD): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    15705150..15707409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00322.2 GenPept UniProtKB/Swiss-Prot:Q00322

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials