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ZNF813 zinc finger protein 813 [ Homo sapiens (human) ]

Gene ID: 126017, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF813provided by HGNC
Official Full Name
zinc finger protein 813provided by HGNC
Primary source
HGNC:HGNC:33257
See related
Ensembl:ENSG00000198346 AllianceGenome:HGNC:33257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 3.4), placenta (RPKM 2.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53467733..53496255)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56547295..56575852)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53970987..53999509)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene Sharpr-MPRA regulatory region 10215 Neighboring gene tropomyosin 3 pseudogene 9 Neighboring gene zinc finger protein 761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53971207-53971768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53971769-53972331 Neighboring gene vomeronasal 1 receptor 102 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:53995337-53996536 Neighboring gene tropomyosin 3 pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54008197-54008422 Neighboring gene ribosomal protein L39 pseudogene 37 Neighboring gene vomeronasal 1 receptor 103 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54022978-54023752 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54023753-54024526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54024527-54025300 Neighboring gene zinc finger protein 331 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54041127-54041643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15071 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:54080110-54081309 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54097943-54098874 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54098875-54099804 Neighboring gene solute carrier family 7 member 3 pseudogene Neighboring gene divergent-paired related homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  2. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
  3. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16542, FLJ34141

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 813

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004301.4 → NP_001004301.2  zinc finger protein 813

    See identical proteins and their annotated locations for NP_001004301.2

    Status: VALIDATED

    Source sequence(s)
    AC022137, AK131422, DB066632, DB235327
    Consensus CDS
    CCDS46172.1
    UniProtKB/Swiss-Prot
    Q6ZN06
    Related
    ENSP00000379684.4, ENST00000396403.9
    Conserved Domains (5) summary
    smart00349
    Location:8 → 48
    KRAB; krueppel associated box
    COG5048
    Location:191 → 602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:525 → 545
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53467733..53496255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56547295..56575852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZN06.2 GenPept UniProtKB/Swiss-Prot:Q6ZN06

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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