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CEACAM20 CEA cell adhesion molecule 20 [ Homo sapiens (human) ]

Gene ID: 125931, updated on 5-Mar-2024

Summary

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Official Symbol
CEACAM20provided by HGNC
Official Full Name
CEA cell adhesion molecule 20provided by HGNC
Primary source
HGNC:HGNC:24879
See related
Ensembl:ENSG00000273777 AllianceGenome:HGNC:24879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ9366
Summary
Predicted to be involved in positive regulation of cytokine production. Predicted to act upstream of or within response to bacterium. Predicted to be located in apical plasma membrane and microvillus membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine (RPKM 13.3), duodenum (RPKM 12.5) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
19q13.31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44506159..44529675, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47331670..47355129, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45010211..45033698, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 285B, pseudogene Neighboring gene MPRA-validated peak3500 silencer Neighboring gene zinc finger protein 180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45003842-45004342 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45004343-45004843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14763 Neighboring gene CEA cell adhesion molecule 22, pseudogene Neighboring gene MPRA-validated peak3502 silencer Neighboring gene Sharpr-MPRA regulatory region 3461 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45081555-45082086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45092773-45093272 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:45097005-45097830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45099482-45100306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45118285-45118786 Neighboring gene immunoglobulin superfamily member 23 Neighboring gene Sharpr-MPRA regulatory region 2639

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tyrosine Phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and Its Functional Role. Daniwijaya EW, et al. Kobe J Med Sci, 2013 Mar 3. PMID 28659570
  2. Role of CEACAM1 and CEACAM20 in an in vitro model of prostate morphogenesis. Zhang H, et al. PLoS One, 2013. PMID 23358633, Free PMC Article
  3. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. Zebhauser R, et al. Genomics, 2005 Nov. PMID 16139472
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tyrosine phosphorylation of CEACAM20 likely promotes phagocytic activity
    Title: Tyrosine Phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and Its Functional Role.
  2. conclude that CEACAM20 and CEACAM1 not only mark the lumina of adult prostate tissue but also play a critical role in the vitro generation of prostate organoids
    Title: Role of CEACAM1 and CEACAM20 in an in vitro model of prostate morphogenesis.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 20
Names
GPAD9366
carcinoembryonic antigen related cell adhesion molecule 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102597.3 → NP_001096067.2  carcinoembryonic antigen-related cell adhesion molecule 20 isoform 5L precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5L) represents the longest transcript and encodes the longest isoform (5L).
    Source sequence(s)
    AC245748, AY358129, EU008600
    Consensus CDS
    CCDS74393.1
    UniProtKB/Swiss-Prot
    A0A087WXE1, A0A087WYH6, A0A087WYM6, A0A087WZX4, A0A087X155, A7LFK7, A7LFK8, A7LFK9, A7LFL0, Q6UY09
    Related
    ENSP00000481937.1, ENST00000614924.5
    Conserved Domains (2) summary
    pfam13927
    Location:361 → 420
    Ig_3; Immunoglobulin domain
    cl11960
    Location:266 → 343
    Ig; Immunoglobulin domain

  2. NM_001102598.3 → NP_001096068.2  carcinoembryonic antigen-related cell adhesion molecule 20 isoform 4S precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4S) lacks an alternate in-frame exon in both the central and 3' coding regions, compared to variant 5L, resulting in an isoform (4S) that is shorter than isoform 5L.
    Source sequence(s)
    AC245748, AY358129, EU008600, EU008601
    Consensus CDS
    CCDS74390.1
    UniProtKB/Swiss-Prot
    Q6UY09
    UniProtKB/TrEMBL
    A0A087WYH6, A7LFK7, A7LFK8
    Related
    ENSP00000481812.1, ENST00000620096.4
    Conserved Domains (4) summary
    smart00410
    Location:175 → 247
    IG_like; Immunoglobulin like
    pfam13895
    Location:175 → 247
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:379 → 435
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:266 → 343
    Ig; Immunoglobulin domain

  3. NM_001102599.3 → NP_001096069.2  carcinoembryonic antigen-related cell adhesion molecule 20 isoform 4L precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4L) lacks an alternate in-frame exon in the central coding region, compared to variant 5L, resulting in an isoform (4L) that is shorter than isoform 5L.
    Source sequence(s)
    AC245748, AY358129, EU008600, EU008602
    Consensus CDS
    CCDS74391.1
    UniProtKB/Swiss-Prot
    Q6UY09
    UniProtKB/TrEMBL
    A0A087WZX4, A7LFK7, A7LFK9
    Related
    ENSP00000482943.1, ENST00000614577.4
    Conserved Domains (4) summary
    smart00410
    Location:175 → 247
    IG_like; Immunoglobulin like
    pfam13895
    Location:175 → 247
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:379 → 434
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:266 → 343
    Ig; Immunoglobulin domain

  4. NM_001102600.3 → NP_001096070.2  carcinoembryonic antigen-related cell adhesion molecule 20 isoform 5S precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5S) lacks an alternate in-frame exon in the 3' coding region, compared to variant 5L, resulting in an isoform (5S) that is shorter than isoform 5L.
    Source sequence(s)
    AC245748, AY358129, EU008600, EU008603
    Consensus CDS
    CCDS74392.1
    UniProtKB/Swiss-Prot
    Q6UY09
    UniProtKB/TrEMBL
    A0A087X155, A7LFK7, A7LFL0
    Related
    ENSP00000483912.1, ENST00000611497.4
    Conserved Domains (4) summary
    smart00410
    Location:361 → 433
    IG_like; Immunoglobulin like
    pfam13895
    Location:369 → 435
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:472 → 528
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:266 → 343
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44506159..44529675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526430.3 → XP_011524732.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X2

    Conserved Domains (4) summary
    smart00410
    Location:388 → 460
    IG_like; Immunoglobulin like
    pfam13895
    Location:396 → 462
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:499 → 555
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:293 → 370
    Ig; Immunoglobulin domain

  2. XM_011526429.3 → XP_011524731.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X1

    Conserved Domains (4) summary
    smart00410
    Location:388 → 460
    IG_like; Immunoglobulin like
    pfam13895
    Location:396 → 462
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:499 → 554
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:293 → 370
    Ig; Immunoglobulin domain

  3. XM_011526432.3 → XP_011524734.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X4

    Conserved Domains (4) summary
    smart00410
    Location:107 → 179
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 181
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:218 → 273
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:12 → 89
    Ig; Immunoglobulin domain

  4. XM_011526431.3 → XP_011524733.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X3

    Conserved Domains (4) summary
    smart00410
    Location:388 → 460
    IG_like; Immunoglobulin like
    pfam13895
    Location:396 → 462
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:499 → 554
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:293 → 370
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    47331670..47355129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319740.1 → XP_054175715.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X2

  2. XM_054319739.1 → XP_054175714.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X1

  3. XM_054319742.1 → XP_054175717.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X4

  4. XM_054319741.1 → XP_054175716.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198444.1: Suppressed sequence

    Description
    NM_198444.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UY09.2 GenPept UniProtKB/Swiss-Prot:Q6UY09

Gene LinkOut

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Chemical Information
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