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30 DNA ligase [ Escherichia phage T4 ]

Gene ID: 1258680, updated on 12-Jan-2023

Summary

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Gene symbol
30
Gene description
DNA ligase
Locus tag
T4p202
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia phage T4 (nat-host: Escherichia coli)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Straboviridae; Tevenvirinae; Tequatrovirus
Also known as
lig
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Genomic context

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Sequence:
NC_000866.4 (125745..127208, complement)

NC_000866.4Genomic Context describing neighboring genes Neighboring gene Alt.-2 hypothetical protein Neighboring gene Alt.-1 hypothetical protein Neighboring gene Alt-like RNA polymerase ADP-ribosyltransferase Neighboring gene Alt.1 conserved hypothetical protein Neighboring gene DUF3045 domain-containing protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene gp30.3' hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000866.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction. Shi K, et al. Nucleic Acids Res, 2018 Nov 2. PMID 30169742, Free PMC Article
  2. Kinetic characterization of single strand break ligation in duplex DNA by T4 DNA ligase. Lohman GJS, et al. J Biol Chem, 2011 Dec 23. PMID 22027837, Free PMC Article
  3. Direct comparison of nick-joining activity of the nucleic acid ligases from bacteriophage T4. Bullard DR, et al. Biochem J, 2006 Aug 15. PMID 16671895, Free PMC Article
  4. Bacteriophage T4 genome. Miller ES, et al. Microbiol Mol Biol Rev, 2003 Mar. PMID 12626685, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The alpha-helical DNA-binding domain (DBD) of T4 DNA ligase exhibits structural homology to the core DNA-binding helices of the larger DBDs from eukaryotic and archaeal DNA ligases.
    Title: T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction.
  2. Kinetic characterization of single strand break ligation in duplex DNA by T4 DNA ligase
    Title: Kinetic characterization of single strand break ligation in duplex DNA by T4 DNA ligase.
  3. To unravel the biochemical and functional relationship between Rnl1, Rnl2, and Dnl, a systematic analysis of their substrate specificity was performed using recombinant proteins
    Title: Direct comparison of nick-joining activity of the nucleic acid ligases from bacteriophage T4.
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General gene information

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Homology

General protein information

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Preferred Names
DNA ligase
NP_049813.1
  • gp30; lig; ATP-dependent DNA ligase; catalyzes formation of a phosphodiester bond between juxtaposed 5' phosphate and 3' hydroxyl termini in duplex DNA or RNA; joins blunt and cohesive ends and repairs single stranded nicks in duplex DNA, RNA or DNA/RNA hybrids; necessary during T4 replication to ligate individual lagging strand DNA synthesis fragments into a continuous polymer

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000866.4 Reference assembly

    Range
    125745..127208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_049813.1 DNA ligase [Escherichia phage T4]

    See identical proteins and their annotated locations for NP_049813.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00970
    UniProtKB/TrEMBL
    A0A023ZUP5, A0A097J7H2, A0A097J877, A0A7S9SUA9, D9IEN7
    Conserved Domains (1) summary
    PHA02587
    Location:1 → 482
    30; DNA ligase; Provisional
Nucleotide Protein
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